Fundación io

Summary

Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros.

This book provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease:

•The host: human and mammalian reservoirs
•The insect vectors: domestic and sylvatic vectors
•The causative parasite: Trypanosoma cruzi

Table of contents

PART I - GENERAL ASPECTS 1. History of the discovery of the American Trypanosomiasis (Chagas disease) Tania Araujo-Jorge, Jenny Telleria, and Jaime Rios Dalenz 2. Chagas disease in pre-Colombian civilizations Felipe Guhl and Arthur Aufderheide 3. Social and Medical aspects: morbidity and mortality in the general populationJoão Carlos Pinto Dias and Christopher John Schofield 4. Current trends and future prospects for control of Chagas disease Álvaro Moncayo and Antonio Carlos Silveira 5. Geographical distribution of Chagas disease James S. Patterson and Felipe Guhl
PART II - INSECT VECTORS 6. Classification and Phylogeny of the TriatominaeMaria Dolores Bargues, Chris Schofield and Jean-Pierre Dujardin 7. Biology of Triatominae François Noireau and Jean-Pierre Dujardin 8. Population Genetics of TriatominesFernando Monteiro, Paula Marcet and Patricia Dorn 9. Geographical distribution of Triatominae vectors in AmericaDavid Gorla and François Noireau 10. Control strategies against Triatominae D.E.Gorla, C.Ponce, J-P.Dujardin and C.J.Schofield
PART III - NON-HUMAN MAMMALIAN HOSTS 11. Domestic and wild mammalian reservoirs Ana Maria Jansen and André Luiz Rodrigues Roque 12. Veterinary aspects and experimental studiesMarc Desquesnes and Marta de Lana
PART IV - THE CAUSATIVE AGENT: TRYPANOSOMA CRUZI 13. Classification and phylogeny of Trypanosoma cruzi Patrick B. Hamilton and Jamie R. Stevens 14. Biology of Trypanosoma cruzi and biological diversity Marta de Lana and Evandro Marques de Menezes Machado 15. Biochemistry of Trypanosoma cruzi Roberto Docampo and Silvia N. J. Moreno 16. Ultrastructure of Trypanosoma cruzi and its Interaction with Host CellsWanderley de Souza, Tecia Ulisses de Carvalho, Emile Santos Barrias 17. Genetics of Trypanosoma cruzi Sub-chapter: Nuclear genome Daniella C. Bartholomeu, Gregory A. Buck, Santuza M. R. Teixeira, Najib M. A. El- SayedSub-chapter: Kinetoplast genome Jenny Telleria, Michal Svoboda 18. Experimental and Natural recombination in Trypanosoma cruziMichael D. Lewis, Martin S. Llewellyn, Matthew Yeo, Michael A. Miles 19. Reticulate Evolution in Trypanosoma cruzi: medical and epidemiological implicationsMichel Tibayrenc, Christian Barnabé and Jenny Telleria 20. Implications of Trypanosoma cruzi intraspecific diversity in the pathogenesis of Chagas DiseaseAndrea Macedo
PART V - MODES OF TRANSMISSION 21. Vector transmission Simone Frédérique Brenière, Christine Aznar and Mireille Hontebeyrie 22. Maternal-fetal transmission of Trypanosoma cruziYves Carlier and Carine Truyens 23. Other forms of transmission Mireille Hontebeyrie, Simone Frédérique Brenière and Christine Aznar
PART VI - IMMUNOLOGY: HOST-PARASITE INTERACTION 24. Protective host response to parasite and its limitations Carine Truyens and Yves Carlier 25. Pathological consequences of host response to parasite Mireille Hontebeyrie , Carine Truyens and Simone Frédérique Brenière 26. Human genetic susceptibility to Chagas diseaseMichel Tibayrenc
PART VII - PATHOLOGY, DIAGNOSIS AND TREATMENT 27. Clinical phases and forms of Chagas’ diseaseJoffre Marcondes de Rezende, Anis Rassi, Alejandro O. Luquetti and Anis Rassi Junior 28. Diagnosis of Trypanosoma cruzi infectionAlejandro O. Luquetti and Gabriel A. Schmuñis 29. AIDS and Chagas’ disease Marcelo Corti, María F. Villafañe 30. Treatment of Chagas diseaseWerner Apt 31. Vaccine development for Chagas disease Angel Marcelo Padilla, Cecilia Perez Brandan and Miguel Angel Basombrío

Authors

Telleria, J. - Tibayrenc, M.