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Summary

After more than four decades of working on the frontlines in the war against malaria, author Irwin W. Sherman is uniquely qualified to present this chronicle of the search for medicines to conquer malaria. The book not only reviews the history of antimalarial medicines, it also explains the hurdles that lie ahead in the discovery and development of effective treatments and control strategies. Moreover, it provides new perspectives on the creative process of drug discovery as well as the challenges of overcoming drug resistance.

Magic Bullets To Conquer Malaria provides a historical overview of the medicines that have been used to treat malaria. It recounts how these drugs were discovered, how they have been used, and why they have failed to eradicate this disease. In addition, readers will learn about the use of larvicides, bednets, and DDT as well as recombinant DNA and monoclonal antibodies to block malaria transmission from mosquitoes to humans.

Autors

Irwin W. Sherman

Table of contents

From Breathing Bad Air to Biting Beasts
2.  Myth to Medicine: Quinine
3.  Synthetic Dyes to Drugs: Atabrine and Chloroquine
4.  Antimicrobials to Antimalarials: Prontosil, Pyrimethamine, Proguanil, and Atovaquone
5.  To Destroy Liver Stages: Primaquine and Tafenoquine
6.  Quinine to Mefloquine
7.  Reversal of Fortune
8.  Sweet Wormwood of Success: Qinghaosu
9.  Antibiotics and the Apicoplast
10. A Possible Dream: Control by Blocking Transmission
11. The Dream of Eradication
12. A Reasonable Dream